Amitriptyline . Elavil®, Endep®, Amitriptyline by Mylan,. Metabolism of tricyclic antidepressants may be altered in patients with hepatic impairment. AMITRIPTYLINE: Antidepressant Pharmacology: Amitriptyline is a tertiary amine tricyclic antidepressant. The manner in which the tricyclic antidepressants exert their. Amitriptyline / ˌ æ m ɪ ˈ t r ɪ p t ɪ l iː n / (Elavil, Endep, Levate, and many others) is the most widely used tricyclic antidepressant (TCA). It is used to. Amitriptyline HCl is an antidepressant with sedative effects. Its mechanism of action in man is not known.. Other metabolic pathways may be involved. Learn about the prescription medication Elavil (Amitriptyline), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. We investigated to compare species differences in amitriptyline (AMI) metabolism among mouse, rat, dog, and human liver microsomes. We developed a method for si 1. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. Increased metabolism of amitriptyline when compared to extensive metabolizers. Consider alternative drug not metabolized by CYP2C19. If a tricyclic is warranted,. Amitriptyline is an anti-depressant that is also used for neurological pain. One of its side effects is weight gain, but I am not sure if it slows metabolism. 1. Ther Drug Monit. 1991 Mar;13(2):177-82. Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer. Brands, Medical Use, Clinical Data. Drug Category. Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Adrenergic Uptake Inhibitors; Dosage Forms Amitriptyline official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. 1. Mayo Clin Proc. 1979 Oct;54(10):669-74. Tricyclic antidepressants and histamine H1 receptors. Richelson E. Tricyclic antidepressants and some structurally related. Amitriptyline hcl is in a class of drugs called tricyclic antidepressants. It is a potent antidepressant with strong sedative properties. AMITRIPTYLINE: Antidepressant Pharmacology: Amitriptyline is a tertiary amine tricyclic antidepressant. The manner in which the tricyclic antidepressants exert their. Jun 02, 2014 · Introduction. Amitriptyline is a tricyclic antidepressant that is widely used in the therapy of depression. Amitriptyline can cause mild and transient. Ask your doctor before using amitriptyline together with ethanol, this can alter the effects of amitriptyline and cause increased side effects. Amitriptyline / ˌ æ m ɪ ˈ t r ɪ p t ɪ l iː n / (Elavil, Endep, Levate, and many others) is the most widely used tricyclic antidepressant (TCA). It is used to. 1. J Pain. 2005 Oct;6(10):644-9. Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Learn about the prescription medication Elavil (Amitriptyline), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling..